https://www.webmd.com/lung/news/20201113/study-new-coronavirus-mutation-accelerates-spread

Study: New Mutation Sped Up Spread of Coronavirus

The virus that causes COVID-19 is not the same strain as what first emerged from China. A new study shows it has changed slightly in a way that makes it more contagious to humans.

Compared to the original strain, people infected with the new strain -- called 614G -- have higher viral loads in their nose and throat, though they don’t seem to get any sicker. But they are much more contagious to others.

Baric and his team also wondered if the changes to the structure of the virus would affect how future therapies -- including a vaccine -- might work against it, since all the treatments now in development have been designed to counter the original strain that emerged from China.

There’s work being done to confirm that at least one of those strains -- the so-called cluster 5 virus -- may have evolved enough changes to its spike proteins that help it escape the vaccine.

Baric says the research needs to be verified, but early work suggests that the virus appears to have changed to help it infect minks more efficiently, while also keeping its ability to infect humans.

https://www.tribdem.com/coronavirus/penn-state-researchers-virus-evolution-could-undermine-a-covid-19-vaccine-but-this-can-be/article_c7a1aac1-65df-5b42-923b-d3e549d8122b.html

Penn State researchers: Virus evolution could undermine a COVID-19 vaccine

The first drug against HIV brought dying patients back from the brink. But as excited doctors raced to get the miracle drug to new patients, the miracle melted away. In each and every patient, the drug only worked only for a while.

It turned out the drug was very good at killing the virus, but the virus was even better at evolving resistance to the drug. A spontaneous mutation in the virus’ genetic material prevented the drug from doing its work, and so the mutant viruses were able to replicate wildly despite the drug, making the patients sick again. It took another decade before scientists found evolution-proof therapies.

Could the same thing happen to a COVID-19 vaccine? Could a vaccine that is safe and effective in initial trials go on to fail because the virus evolves its way out of trouble?

https://www.tribdem.com/coronavirus/penn-state-researchers-virus-evolution-could-undermine-a-covid-19-vaccine-but-this-can-be/article_c7a1aac1-65df-5b42-923b-d3e549d8122b.html

Penn State researchers: Virus evolution could undermine a COVID-19 vaccine

The first drug against HIV brought dying patients back from the brink. But as excited doctors raced to get the miracle drug to new patients, the miracle melted away. In each and every patient, the drug only worked only for a while.

It turned out the drug was very good at killing the virus, but the virus was even better at evolving resistance to the drug. A spontaneous mutation in the virus’ genetic material prevented the drug from doing its work, and so the mutant viruses were able to replicate wildly despite the drug, making the patients sick again. It took another decade before scientists found evolution-proof therapies.

Could the same thing happen to a COVID-19 vaccine? Could a vaccine that is safe and effective in initial trials go on to fail because the virus evolves its way out of trouble?

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QR result leak?

No troll please

https://www.theaustralian.com.au/world/new-virus-rules-in-madrid-as-spain-mulls-national-emergency/news-story/8448be1dd44a0558a36286c9bddbfe5f

New virus rules in Madrid as Spain mulls national emergency


New coronavirus restrictions were taking effect in Madrid on Saturday as the Spanish government weighed declaring a national state of emergency to allow curfews to be imposed.

https://www.theaustralian.com.au/world/new-virus-rules-in-madrid-as-spain-mulls-national-emergency/news-story/8448be1dd44a0558a36286c9bddbfe5f

New virus rules in Madrid as Spain mulls national emergency

New coronavirus restrictions were taking effect in Madrid on Saturday as the Spanish government weighed declaring a national state of emergency to allow curfews to be imposed.

Good job newbie8080

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Better not get involved with call warrant as it is more of a gambling rather than investment. Most likely you will lose gaogao by the manipulation, exploitation and outright cheating of the IB. Perhaps the odds is better if you go to Genting, Macau or Las Vegas instead of gambling in call warrant

No need to go overboard, our gloves and stock market should still be okay even with the emergency declared as it is due to Covid-19 pandemic and not due to violences

No need to go overboard, our gloves and stock market should still be okay even ith the emrgency declared as it is due to Covid-19 and not due to violences

https://www.nst.com.my/news/nation/2020/10/634921/other-countries-too-have-declared-state-emergency-control-covid-19-spread

Other countries too have declared state of emergency to control Covid-19 spread

A tracking tool developed by Swiss-based Centre for Civil and Political Rights, a total of 79 states across the world have invoked a state of emergency that entails several forms of measures in response to the pandemic.

https://www.nst.com.my/news/nation/2020/10/634921/other-countries-too-have-declared-state-emergency-control-covid-19-spread

Other countries too have declared state of emergency to control Covid-19 spread

A tracking tool developed by Swiss-based Centre for Civil and Political Rights, a total of 79 states across the world have invoked a state of emergency that entails several forms of measures in response to the pandemic.

https://www.theedgemarkets.com/article/remdesivir-hydroxychloroquine-found-not-effective-covid19-treatment

Remdesivir, Hydroxychloroquine found not effective in Covid-19 treatment

Antivirus medicines such as remdesivir have been found to be ineffective in treating Covid-19 patients as well as not helpful in reducing death cases of the outbreak.

Health director-general Tan Sri Dr Noor Hisham Abdullah said clinical studies by the World Health Organization (WHO) Solidarity trial proved that anti-malaria medicine hydroxychloroquine as well as lopinavir and ritonavir are not effective in treating the disease

https://www.theedgemarkets.com/article/remdesivir-hydroxychloroquine-found-not-effective-covid19-treatment

Remdesivir, Hydroxychloroquine found not effective in Covid-19 treatment

Antivirus medicines such as remdesivir have been found to be ineffective in treating Covid-19 patients as well as not helpful in reducing death cases of the outbreak.

Health director-general Tan Sri Dr Noor Hisham Abdullah said clinical studies by the World Health Organization (WHO) Solidarity trial proved that anti-malaria medicine hydroxychloroquine as well as lopinavir and ritonavir are not effective in treating the disease

https://www.theedgemarkets.com/article/remdesivir-hydroxychloroquine-found-not-effective-covid19-treatment

Remdesivir, Hydroxychloroquine found not effective in Covid-19 treatment

Antivirus medicines such as remdesivir have been found to be ineffective in treating Covid-19 patients as well as not helpful in reducing death cases of the outbreak.

Health director-general Tan Sri Dr Noor Hisham Abdullah said clinical studies by the World Health Organization (WHO) Solidarity trial proved that anti-malaria medicine hydroxychloroquine as well as lopinavir and ritonavir are not effective in treating the disease.

https://www.theedgemarkets.com/article/remdesivir-hydroxychloroquine-found-not-effective-covid19-treatment

Remdesivir, Hydroxychloroquine found not effective in Covid-19 treatment

Antivirus medicines such as remdesivir have been found to be ineffective in treating Covid-19 patients as well as not helpful in reducing death cases of the outbreak.

Health director-general Tan Sri Dr Noor Hisham Abdullah said clinical studies by the World Health Organization (WHO) Solidarity trial proved that anti-malaria medicine hydroxychloroquine as well as lopinavir and ritonavir are not effective in treating the disease.

https://www.npr.org/2020/10/16/924648126/update-on-coronavirus-vaccine-and-drugs

Update On Coronavirus Vaccine And Drugs

Pfizer announced Friday there would be no coronavirus vaccine before the election. And a new study questioned the effectiveness of remdesivir, a drug used to treat hospitalized COVID-19 patients.

https://www.npr.org/2020/10/16/924648126/update-on-coronavirus-vaccine-and-drugs

Update On Coronavirus Vaccine And Drugs

Pfizer announced Friday there would be no coronavirus vaccine before the election. And a new study questioned the effectiveness of remdesivir, a drug used to treat hospitalized COVID-19 patients.

Coronavirus update: Global COVID-19 cases top 39 million as trial of promising therapy finds it does not stop patients dying

The trial, conducted by the World Health Organization, found that remdesivir, as well as hydroxychloroquine, and lopinavir/ritonavir and interferon had “little or no effect” on overall mortality, ventilation, and length of hospital stay among 11,330 participating patients.

The Food and Drug Administration has authorized remdesivir as a COVID-19 treatment, based on a clinical study conducted in the U.S. that found the drug could reduce recovery times.
It had also granted an emergency use authorization to hydroxychloroquine as a COVID-19 treatment although it was rescinded this summer.

The WHO study was first reported by the Financial Times on Thursday.

Coronavirus update: Global COVID-19 cases top 39 million as trial of promising therapy finds it does not stop patients dying

The trial, conducted by the World Health Organization, found that remdesivir, as well as hydroxychloroquine, and lopinavir/ritonavir and interferon had “little or no effect” on overall mortality, ventilation, and length of hospital stay among 11,330 participating patients.

The Food and Drug Administration has authorized remdesivir as a COVID-19 treatment, based on a clinical study conducted in the U.S. that found the drug could reduce recovery times.
It had also granted an emergency use authorization to hydroxychloroquine as a COVID-19 treatment although it was rescinded this summer.

The WHO study was first reported by the Financial Times on Thursday.

Remdesivir and interferon fall flat in WHO’s megastudy of COVID-19 treatments

One of the world’s biggest trials of COVID-19 therapies released its long-awaited interim results yesterday—and they’re a letdown.

None of the four treatments in the Solidarity trial, which enrolled more than 11,000 patients in 400 hospitals around the globe, increased survival—not even the much-touted antiviral drug remdesivir.

Scientists at the World Health Organization (WHO) released the data as a preprint on medRxiv last night, ahead of its planned publication in The New England Journal of Medicine.

Remdesivir and interferon fall flat in WHO’s megastudy of COVID-19 treatments

One of the world’s biggest trials of COVID-19 therapies released its long-awaited interim results yesterday—and they’re a letdown.

None of the four treatments in the Solidarity trial, which enrolled more than 11,000 patients in 400 hospitals around the globe, increased survival—not even the much-touted antiviral drug remdesivir.

Scientists at the World Health Organization (WHO) released the data as a preprint on medRxiv last night, ahead of its planned publication in The New England Journal of Medicine.

What’s the difference between an EUA (emergency-use authorization) and an approval of a vaccine?

EUAs are the primary way that the FDA is handling regulatory authorization of medical products used to prevent or treat infections caused by the coronavirus under authority granted during the public health emergency. However, an EUA is no longer valid once the emergency is over.

Some public health experts have warned, however, that, when it comes to vaccines, the limitations of the EUA process may be misunderstood by the public.

Such an approach should only be used cautiously for COVID-19 vaccines because the public may perceive an EUA as the same as approval.

The FDA issued guidance that recommends COVID-19 vaccines meet a threshold of being effective 50% of the time, which would make a coronavirus vaccine similar in effectiveness to a flu vaccine.

What’s the difference between an EUA (emergency-use authorization) and an approval of a vaccine?

EUAs are the primary way that the FDA is handling regulatory authorization of medical products used to prevent or treat infections caused by the coronavirus under authority granted during the public health emergency. However, an EUA is no longer valid once the emergency is over.

Some public health experts have warned, however, that, when it comes to vaccines, the limitations of the EUA process may be misunderstood by the public.

Such an approach should only be used cautiously for COVID-19 vaccines because the public may perceive an EUA as the same as approval.

The FDA issued guidance that recommends COVID-19 vaccines meet a threshold of being effective 50% of the time, which would make a coronavirus vaccine similar in effectiveness to a flu vaccine.

https://www.reuters.com/article/health-coronavirus-fda/us-fda-panel-to-discuss-covid-19-vaccine-trials-after-emergency-authorization-idUSL4N2HC3UV

FDA panel to discuss COVID-19 vaccine trials after emergency authorization

(Reuters) - A panel of independent experts to the U.S. health regulator will decide on the nature of clinical trials that coronavirus vaccines should go through after receiving U.S. emergency use authorization.

“Emergency use authorization will be granted to a vaccine that shows a very good safety profile and efficacy at or around 60%, but I don’t think the vaccine trials right now are being run very scientifically,” said Jared Holz, healthcare strategist for brokerage Jefferies.

The U.S. government’s efforts to speed development of a COVID-19 vaccine has led to concerns of political interference in the regulatory process at the expense of safety.

https://www.reuters.com/article/health-coronavirus-fda/us-fda-panel-to-discuss-covid-19-vaccine-trials-after-emergency-authorization-idUSL4N2HC3UV

FDA panel to discuss COVID-19 vaccine trials after emergency authorization

(Reuters) - A panel of independent experts to the U.S. health regulator will decide on the nature of clinical trials that coronavirus vaccines should go through after receiving U.S. emergency use authorization.

“Emergency use authorization will be granted to a vaccine that shows a very good safety profile and efficacy at or around 60%, but I don’t think the vaccine trials right now are being run very scientifically,” said Jared Holz, healthcare strategist for brokerage Jefferies.

The U.S. government’s efforts to speed development of a COVID-19 vaccine has led to concerns of political interference in the regulatory process at the expense of safety.

LONDON (Reuters) - The coronavirus will be around for “evermore” as it is unlikely it will be eradicated, a British scientist on the government’s advisory committee for the pandemic said on Wednesday, although a vaccine would help improve the situation.

LONDON (Reuters) - The coronavirus will be around for “evermore” as it is unlikely it will be eradicated, a British scientist on the government’s advisory committee for the pandemic said on Wednesday, although a vaccine would help improve the situation.

https://www.reuters.com/article/health-coronavirus-britain-sage/update-1-uk-scientific-advisor-says-coronavirus-unlikely-to-be-eradicated-idUSL8N2HC317

UK scientific advisor says coronavirus unlikely to be eradicated

“We are going to have to live with this virus for evermore. There is very little chance that it’s going to become eradicated,” John Edmunds, a member of Scientific Advisory Group for Emergencies (SAGE), told lawmakers.

https://www.reuters.com/article/health-coronavirus-britain-sage/update-1-uk-scientific-advisor-says-coronavirus-unlikely-to-be-eradicated-idUSL8N2HC317

UK scientific advisor says coronavirus unlikely to be eradicated

“We are going to have to live with this virus for evermore. There is very little chance that it’s going to become eradicated,” John Edmunds, a member of Scientific Advisory Group for Emergencies (SAGE), told lawmakers.

https://www.investing.com/news/coronavirus/volunteer-in-oxford-covid19-vaccine-trial-has-died-brazil-health-authority-says-2330069

AstraZeneca COVID-19 vaccine trial Brazil volunteer dies, trial to continue

Covid-19 vaccine is not a silver bullet. FYI, target effectiveness of the vaccines under development are about 50-60% only. Similar with the flu vaccine which is about 50-60% effectiveness also and the flu has been around for ages without being eradicated.

FYI target effectiveness of the vaccines under development are about 50-60% only. Similar with the flu vaccine and the flu has been around for ages without being eradicated.

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Smart investors earned millions but did not make so much noise like the henchmen..ha..ha

30 years experiences henchman but earned peanuts

A short live joy for the evil henchmen gang today...lol
Anyway have to thanks them for me being able to collect on cheap...ha..ha

Brilliant, good job Freetospeak

Target effectiveness for the vaccines under development are 50-60%, about the same with flu vaccine. Flu have been around for ages without being eradicated although the vaccine is available.

Target Effectiveness is only 60%, same as flu vaccine

Vaccine: BioNTech BNTX, +4.10% and Pfizer Inc. PFE, +3.83%

Year-to-date stock performances: BioNTech, up 75%; Pfizer, down 8.3%.

Name: BNT162b2.

Type: mRNA.

Phase 1: The companies published preliminary data on July 1 for BNT162b1 as a preprint. They said then that 24 participants in the study who received two doses of the lower-dose vaccine developed neutralizing antibodies. A second preprint was published on Aug. 28 for BNT162b2 that found this candidate produced similar levels of antibodies but participants reported fewer reactions.

Phase 2/3: This trial is expected to focus on BNT162b2. It is expected to enroll up to 30,000 participants in Argentina, Brazil and the U.S. This is the trial protocol.

Target effectiveness: 60%

Dosing: 2 doses.

https://www.marketwatch.com/story/heres-what-you-need-to-know-about-clinical-trials-as-drug-makers-push-forward-with-coronavirus-vaccine-studies-2020-09-11?mod=article_inline

What’s the difference between an EUA (emergency-use authorization) and an approval of a vaccine?
EUAs are the primary way that the FDA is handling regulatory authorization of medical products used to prevent or treat infections caused by the coronavirus under authority granted during the public health emergency. However, an EUA is no longer valid once the emergency is over.

Some public health experts have warned, however, that, when it comes to vaccines, the limitations of the EUA process may be misunderstood by the public.

Such an approach should only be used cautiously for COVID-19 vaccines because the public may perceive an EUA as the same as approval.

The FDA issued guidance that recommends COVID-19 vaccines meet a threshold of being effective 50% of the time, which would make a coronavirus vaccine similar in effectiveness to a flu vaccine.

https://www.marketwatch.com/story/heres-what-you-need-to-know-about-clinical-trials-as-drug-makers-push-forward-with-coronavirus-vaccine-studies-2020-09-11?mod=article_inline

What’s the difference between an EUA (emergency-use authorization) and an approval of a vaccine?

EUAs are the primary way that the FDA is handling regulatory authorization of medical products used to prevent or treat infections caused by the coronavirus under authority granted during the public health emergency. However, an EUA is no longer valid once the emergency is over.

Some public health experts have warned, however, that, when it comes to vaccines, the limitations of the EUA process may be misunderstood by the public.

Such an approach should only be used cautiously for COVID-19 vaccines because the public may perceive an EUA as the same as approval.

The FDA issued guidance that recommends COVID-19 vaccines meet a threshold of being effective 50% of the time, which would make a coronavirus vaccine similar in effectiveness to a flu vaccine.

"So let me be clear, ASSUMING POSITIVE DATA, Pfizer will apply for Emergency Authorisation Use in the US soon after the safety milestone is achieved in the third week of November," the company's chairman and CEO Albert Bourla said in an open letter.

Definition of silver bullet
: something that acts as a magical weapon
especially : one that instantly solves a long-standing problem

https://www.malaymail.com/news/malaysia/2020/09/22/dr-noor-hisham-vaccine-not-silver-bullet-solution-to-covid-19-adhering-to-s/1905619

Dr Noor Hisham: Vaccine not ‘silver-bullet solution’ to Covid-19

https://www.bbc.com/news/world-53643455

Coronavirus: WHO warns of 'no silver bullet' amid vaccine search

The head of the World Health Organization (WHO) has said that while there is hope for a vaccine against Covid-19, one might never be found.

Tedros Adhanom Ghebreyesus told a news briefing there was "no silver bullet at the moment - and there might never be".