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Top Glove : The E484 mutation

pBlue
Publish date: Sun, 17 Jan 2021, 01:23 PM
pBlue
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PBlue a buy and hold investor and occasional swing trader on the side.

Abstract

The E484, mutation found in emerging SARS-Cov2 viral lineages in Soouth Africa and Brazil reduces neutralization by antibodies from covid19 patients by >10 fold.  While the E484 mutation causes significant reduction of antibody binding, it is not the only mutation, other mutations like  G485R and S494P also caused lesser but still appreciable (~3 to 5-fold) decreases in neutralization titer

https://www.biorxiv.org/content/10.1101/2020.12.31.425021v1.full.pdf

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